Xencor

Xencor's employees are the most important factor in our success. We have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.

We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.

We offer a competitive salary & benefits package. Xencor is an equal employment opportunity employer.

Information and resumes: recruiting@xencor.com

Employee Benefits

• Competitive base salary and bonus program
• Stock options
• Scientific and performance award programs
• 401k plan
• Health Insurance
• Dental Insurance
• Medical/dependent care reimbursement plan
• Group Life Insurance
• Group AD&D Insurance
• Long Term Disability
• Generous vacation/sick/holiday time

Xencor reserves the right to change or terminate the above benefits at any time with or without notice.

Current openings

Research Associate, Pharmacology

RESPONSIBILITIES AND JOB SPECIFICATIONS

Candidate will primarily assist with in vivo studies focused on identifying therapeutic antibody candidates in the areas of oncology and autoimmune disease. Candidate will also be required to perform laboratory work, including in vitro assays and cell culture. In vivo responsibilities will include animal handling and husbandry, injections, data collection and analysis, monitoring of animal health, presentation of data in graphs and charts. Laboratory responsibilities will include reagent preparation and ordering, cell culture, ELISA, assistance with preparation of vialed test articles for contract studies, and detailed record-keeping.

REQUIREMENTS

Candidate must be well organized, detail-oriented, able to work independently, have excellent oral and written communication skills and able to work in a team environment. Bachelor’s degree in the biological sciences and experience with animal models required.

Director/Senior Director, Manufacturing, Technical Operations

SUMMARY DESCRIPTION

Direct all manufacturing operations for Xencor products at Contract Manufacturing Organizations (CMOs). Provide strong, effective technical and managerial leadership for Manufacturing, Process Development and Analytical Sciences. Establish and maintain strong, collaborative working relationships between Manufacturing and other functional areas/departments. Contribute significantly to development and implementation of Xencor’s product development and manufacturing strategies.

Job will involve significant travel to contract manufacturing sites (estimated up to 25%).

RESPONSIBLITIES

• Day-to-day management/oversight of technology transfer and manufacturing activities at CMOs for Xencor products. Serve as the primary contact for all manufacturing-related communications and interactions between CMOs and Xencor.
• Develop and implement standard policies and procedures for evaluation and selection of CMOs. Coordinate and lead internal teams (including consultants as required) for identification, evaluation and selection of CMOs.
• Coordinate technology transfer activities between Xencor and CMOs.
• Manage and direct the efforts of the Process Development and Analytical Sciences functions.
• Work closely with internal providers (Research, Quality) and customers (Preclinical Development, Clinical Development, Project Management) to ensure that corporate objectives are met.
• Participate in manufacturing site audits (technical and/or GMP) as required.
• Coordinate technical, business, and legal review and revision of development and manufacturing agreements with CMOs for Xencor products.
• Serve as member/leader of CMC project sub teams for Xencor development programs as appropriate.
• Develop, establish, and manage the clinical supply chain for Xencor development programs, encompassing critical raw materials, production cell banks, drug substance, drug product, and packaging and labeling clinical drug product.
• Coordinate review and approval of CMO manufacturing documents by appropriate Xencor personnel and/or consultants.
• Serve as Xencor’s “Person-In-Plant” at CMO sites for critical manufacturing activities.
• Establish, maintain, and monitor clinical product inventories and production schedules.
• In collaboration with Quality, ensure consistent product quality through development and implementation of appropriate manufacturing systems and controls.
• Develop, implement and update all manufacturing SOPs, Batch Records and other documentation needed for CGMP compliance as needed.
• Serve as primary author for manufacturing sections of regulatory submissions, and as a primary reviewer for all CMC sections of regulatory submissions.
• Develop and manage departmental objectives and operating plans, based on corporate/program core team objectives.
• Provide timely, detailed information to all stakeholders on manufacturing activities, issues, and approaches to resolution of problems.
• Provide reasoned and timely input to company management in developing a structure, vision and strategic plan for manufacturing.
• As a senior manager with Technical Operations, collaborate effectively with peers within the department and other members of internal and external cross-functional teams, outside partners, colleagues and collaborators in industry, and representatives of drug regulatory agencies.
• As needed, develop and retain a cohesive, professional, empowered, high performing team of experienced, qualified manufacturing and technical support staff.
• Set and maintain high standards for individual and team performance and accountability.

SCOPE

Decisions re manufacturing operations, scheduling of manufacturing activities, implementation of process changes have HIGH impact on continuity of drug supply for clinical trials, and eventual commercial manufacturing cost of goods, capital and labor requirements, and manufacturing plan capacity.

Direct responsibility for development and management of departmental operating budget (projected total spending of $3.8MM for 2008-2009).

EDUCATION

• Ph.D. in a scientific discipline (Biology, Chemistry, Biochemistry, Microbiology, Pharmacy, Chemical Engineering, or Biochemical Engineering, with 4-6 years of relevant technical and operations experience (see below), OR
• M.S. in one of the above disciplines, with 6-8 years of relevant experience, OR
• B.S. in one of the above disciplines, with 8-10 years of relevant experience.
• Well-versed in the fundamentals of pharmaceutical GMP’s and pharmaceutical manufacturing operations, drug development and project management.

EXPERIENCE

• 6-8 years of biotech/pharmaceutical industry experience in process development, clinical/commercial manufacturing operations and/or contract manufacturing. Significant (4+ years) direct experience with clinical or commercial manufacturing of biopharmaceutical product(s) highly preferred.
• 2-4 years management experience at Manager level or above; significant (1-2 years) participation on cross-functional project teams as member and/or leader highly preferred.
• Excellent written and verbal communication skills.
• Proficient in use of project planning/scheduling software (e.g. MS Project)

Research Associate 3/Associate Scientist, Protein Chemistry

RESPONSIBILITIES AND JOB SPECIFICATIONS

We are now seeking a creative and energetic Protein Chemist to join our team developing targeted anticancer monoclonal antibodies. We seek a highly motivated scientist to help engineer Xencor's pipeline of novel “XmAb“ antibody therapies. Your work will exploit cutting-edge antibody purification and assay tools, combining exploratory research with biopharmaceutical development in a stimulating multidisciplinary environment. In addition to generating a pipeline of novel drug candidates, Xencor's protein engineering technologies have also been externally endorsed through our collaborative agreements with leading biopharmaceutical companies including Genentech, MedImmune, Roche, Centocor, Lilly, and Chugai.

REQUIREMENTS

The position requires a scientist with experience in diverse areas of protein chemistry, mammalian tissue culture, including small-scale protein expression and purification from mammalian systems, and protein characterization; experience with purification and characterization of antibodies is essential. Experience with cell assays is useful. Excellent organizational skills and ability to work well in a team are a must for this position. Creativity, enthusiasm, and strong oral and written communication skills are a bonus. Requirements: BS or MS in Biochemistry or equivalent degree, with at least two (2) years of relevant post-graduate experience. A proven track record working in a biotech environment is highly preferred.

Lead Scientist

RESPONSIBILITIES AND JOB SPECIFICATIONS

Lead Scientist in Monrovia, California. The Lead Scientist will design, develop, qualify and execute immunoassays and cell based assays to support process development, product release testing and testing of pre-clinical samples.

REQUIREMENTS

Ph.D in Cell and Molecular Biology or related field with a minimum of two years of experience is required. Send cover letter, resume, and transcriptsto Julie Casciani, Xencor Inc., 111 West Lemon Avenue, Monrovia CA 91016

Analytical Sciences Associate (Temporary), Technical Operations/Process Development

RESPONSIBILITIES AND JOB SPECIFICATIONS

Xencor is currently seeking an Analytical Sciences Associate. Please note that this is a temporary position. As part of the team working to develop methods and processes for Xencor’s products, the candidate will be involved in supporting development of methods and purification processes for production of novel therapeutic proteins to support research, pre-clinical studies and early phase clinical production. Specific responsibilities include:

• Qualification of kit based immunoassays.
• Routine immunoassay support of process development.
• Assist in running other analytical techniques.
• Generate, document, analyze, and report results of experiments and present at group or departmental meetings

REQUIREMENTS

• A B.S. or M.S. in biochemistry, biology, or a related field
• 1-3 years related experience in the biopharmaceutical/biotech industrial
• Prior hands-on experiences in immunoassays, and protein assays, past support of process development is highly desirable
• Must possess good interpersonal, communication and team skills, have a strong focus on quality and attention to detail
• Must be highly motivated, be able to work individually as well as in teams, and possesses excellent organization and communication skills.