We seek a Director, Portfolio Management & Strategy, to oversee the assessment and prioritization of the company’s pipeline of monoclonal antibody therapeutics. The incumbent will execute technical and market analysis of the company’s product portfolio i) to support decision-making and resource allocation throughout all stages of R&D and commercialization and ii) to guide product development decisions to align the portfolio with the company’s business and financial strategy. Reports to CEO in Monrovia, CA.


  • Responsible for analyzing, valuing and prioritizing the company’s early stage and clinical monoclonal antibody programs
  • Execute market analyses of the company’s R&D programs, including epidemiology, clinical landscape, commercial and reimbursement environment
  • Conduct competitive analysis for portfolio programs
  • Collaborate with finance function to develop valuation models and operating plans for product portfolio
  • Define portfolio evolution timelines and trade offs
  • Prepare presentations of market and financial analyses and portfolio prioritization for the CEO and Board of Directors
  • Responsible for the overall design, implementation and delivery of all externally contracted product market research and competitive analysis to the organization.
  • Responsible for the development of primary and secondary market research plan and budget
  • Assist R&D management in identification and assessment of new product opportunities
  • Provides market assessment and competitive landscape input for business development of the company’s monoclonal antibody pipeline and antibody optimization technologies


  • Bachelor’s degree required; MBA, MD or PhD in the life sciences or engineering with excellent academic track record preferred


  • A minimum of 3 years experience in a strategy consulting firm providing portfolio strategy support for biotech/pharmaceutical clients plus 2-3 additional years relevant experience in business (or consulting);
    -alternatively, 5+ years in portfolio management, new product planning or corporate strategy role for a company in the biotech/pharmaceutical industry;
    -prefer an additional 2-3 years of team or project leadership in a healthcare R&D or commercial organization

Preferred Skills/Qualifications

  • Epidemiology-based revenue forecasting and asset valuation experience
  • Proven ability to lead multiple projects efficiently and independently, with appropriate communication with senior management
  • Demonstrated expert-level ability and success using written and verbal communication skills to communicate complex scientific, medical and business
  • Strong knowledge and understanding of healthcare industries
  • Ability to partner simultaneously with internal business colleagues and external consultants/experts as needed
  • Outstanding flexibility and adaptability suited for the changing requirements and fast pace of a small biotechnology company


Xencor Inc. is an innovative biotechnology company headquartered in the Los Angeles area near Pasadena and with an office in San Diego. We recently completed a successful initial public offering (IPO). We use our pioneering XmAb® technology to develop better biotherapeutics — antibodies that target new biological mechanisms and are more potent, safer and longer lasting — to improve patient outcomes and quality of life.

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